Biodistribution of adult derived human liver stem cells following intraportal infusion in a 17-year-old patient with glycogenosis type 1A.
Identifieur interne : 000236 ( Main/Exploration ); précédent : 000235; suivant : 000237Biodistribution of adult derived human liver stem cells following intraportal infusion in a 17-year-old patient with glycogenosis type 1A.
Auteurs : RBID : pubmed:24607438Abstract
Current treatment of inherited liver inborn errors of metabolism in children consists in appropriate diet and drugs and, for unstable patients, final orthotopic liver transplantation. Unfortunately, liver transplantation remains not easily available because of organ shortage and imposes inherent risks and lifelong immunosuppressive therapy. Therefore alternative treatments are required. Hepatocytes transplantation and its limitations led to consider innovative alternative such as transplantation of adult derived human liver stem cells (ADLHSC). These cells present high proliferative capacity, good resistance to cryopreservation and ability to differentiate into hepatocyte-like cells displaying mature hepatocyte functions.
DOI: 10.1016/j.nucmedbio.2014.01.010
PubMed: 24607438
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Biodistribution of adult derived human liver stem cells following intraportal infusion in a 17-year-old patient with glycogenosis type 1A.</title><author><name sortKey="Defresne, Florence" uniqKey="Defresne F">Florence Defresne</name><affiliation wicri:level="1"><nlm:affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address: florence.defresne@uclouvain.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Tondreau, Tatiana" uniqKey="Tondreau T">Tatiana Tondreau</name><affiliation wicri:level="1"><nlm:affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Stephenne, Xavier" uniqKey="Stephenne X">Xavier Stéphenne</name><affiliation wicri:level="1"><nlm:affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Smets, Francoise" uniqKey="Smets F">Françoise Smets</name><affiliation wicri:level="1"><nlm:affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Bourgois, Annick" uniqKey="Bourgois A">Annick Bourgois</name><affiliation wicri:level="1"><nlm:affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Najimi, Mustapha" uniqKey="Najimi M">Mustapha Najimi</name><affiliation wicri:level="1"><nlm:affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Jamar, Francois" uniqKey="Jamar F">François Jamar</name><affiliation wicri:level="1"><nlm:affiliation>Cliniques universitaires Saint-Luc, Department of Radiology, Avenue Hippocrate 10, 1200 Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Cliniques universitaires Saint-Luc, Department of Radiology, Avenue Hippocrate 10, 1200 Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Sokal, Etienne M" uniqKey="Sokal E">Etienne M Sokal</name><affiliation wicri:level="1"><nlm:affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address: etienne.sokal@uclouvain.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><date when="2014">2014</date><idno type="doi">10.1016/j.nucmedbio.2014.01.010</idno><idno type="RBID">pubmed:24607438</idno><idno type="pmid">24607438</idno><idno type="wicri:Area/Main/Corpus">000128</idno><idno type="wicri:Area/Main/Curation">000128</idno><idno type="wicri:Area/Main/Exploration">000236</idno></publicationStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Current treatment of inherited liver inborn errors of metabolism in children consists in appropriate diet and drugs and, for unstable patients, final orthotopic liver transplantation. Unfortunately, liver transplantation remains not easily available because of organ shortage and imposes inherent risks and lifelong immunosuppressive therapy. Therefore alternative treatments are required. Hepatocytes transplantation and its limitations led to consider innovative alternative such as transplantation of adult derived human liver stem cells (ADLHSC). These cells present high proliferative capacity, good resistance to cryopreservation and ability to differentiate into hepatocyte-like cells displaying mature hepatocyte functions.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">24607438</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>10</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9614</ISSN><JournalIssue CitedMedium="Internet"><Volume>41</Volume><Issue>4</Issue><PubDate><Year>2014</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Nuclear medicine and biology</Title><ISOAbbreviation>Nucl. Med. Biol.</ISOAbbreviation></Journal><ArticleTitle>Biodistribution of adult derived human liver stem cells following intraportal infusion in a 17-year-old patient with glycogenosis type 1A.</ArticleTitle><Pagination><MedlinePgn>371-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nucmedbio.2014.01.010</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0969-8051(14)00013-4</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Current treatment of inherited liver inborn errors of metabolism in children consists in appropriate diet and drugs and, for unstable patients, final orthotopic liver transplantation. Unfortunately, liver transplantation remains not easily available because of organ shortage and imposes inherent risks and lifelong immunosuppressive therapy. Therefore alternative treatments are required. Hepatocytes transplantation and its limitations led to consider innovative alternative such as transplantation of adult derived human liver stem cells (ADLHSC). These cells present high proliferative capacity, good resistance to cryopreservation and ability to differentiate into hepatocyte-like cells displaying mature hepatocyte functions.</AbstractText><AbstractText Label="AIM" NlmCategory="OBJECTIVE">Biodistribution of ADHLSC had never been assessed after infusion through the portal vein in patients. This information is required to determine the safety of the method.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">ADHLSC were efficiently labelled with 111-Indium DTPA radiotracer and SPECT imaging was used for the acquisition of whole body imaging to document short term biodistribution of ADHLSC.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Following infusion through the portal vein, ADHLSC diffused homogenously throughout the liver and remained strictly within the targeted organ. Images were acquired until 5 days after infusion. At that time, no signal was observed in any other organs except the liver. Urinary excretion of 111-Indium DTPA was also monitored.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">For the first time, we documented the short term biodistribution of ADHLSC within the liver after infusion through the portal vein.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Defresne</LastName><ForeName>Florence</ForeName><Initials>F</Initials><Affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address: florence.defresne@uclouvain.be.</Affiliation></Author><Author ValidYN="Y"><LastName>Tondreau</LastName><ForeName>Tatiana</ForeName><Initials>T</Initials><Affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium.</Affiliation></Author><Author ValidYN="Y"><LastName>Stéphenne</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><Affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium.</Affiliation></Author><Author ValidYN="Y"><LastName>Smets</LastName><ForeName>Françoise</ForeName><Initials>F</Initials><Affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium.</Affiliation></Author><Author ValidYN="Y"><LastName>Bourgois</LastName><ForeName>Annick</ForeName><Initials>A</Initials><Affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium.</Affiliation></Author><Author ValidYN="Y"><LastName>Najimi</LastName><ForeName>Mustapha</ForeName><Initials>M</Initials><Affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium.</Affiliation></Author><Author ValidYN="Y"><LastName>Jamar</LastName><ForeName>François</ForeName><Initials>F</Initials><Affiliation>Cliniques universitaires Saint-Luc, Department of Radiology, Avenue Hippocrate 10, 1200 Brussels, Belgium.</Affiliation></Author><Author ValidYN="Y"><LastName>Sokal</LastName><ForeName>Etienne M</ForeName><Initials>EM</Initials><Affiliation>Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Paediatric Hepatology and Cell Therapy, Avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address: etienne.sokal@uclouvain.be.</Affiliation></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Nucl Med Biol</MedlineTA><NlmUniqueID>9304420</NlmUniqueID><ISSNLinking>0969-8051</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Biodistribution</Keyword><Keyword MajorTopicYN="N">Glycogenosis</Keyword><Keyword MajorTopicYN="N">Hepatic progenitor cells</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>12</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>1</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>1</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>1</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>3</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>3</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0969-8051(14)00013-4</ArticleId><ArticleId IdType="doi">10.1016/j.nucmedbio.2014.01.010</ArticleId><ArticleId IdType="pubmed">24607438</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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